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In addition, the high penetration level through the stratum corneum alone can be explained by the fact that there was no tissue retention from underlying skin that may have limited penetration

Currently, liver diseases, including various forms of liver injury, metabolic-associated fatty liver disease (MAFLD), liver fibrosis and hepatocellular carcinoma (HCC), are an increasingly serious global public health problem with rising prevalence rates that pose a significant threat to patients quality of life and survival ( Natural products have become a focus of research in drug development and disease prevention due to their structural diversity, significant biological activities and relatively high safety profile (Yan et al., 2020)

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The liver contains the highest concentrations of glutathione in the body, where it neutralises harmful free radicals, supports phase II detoxification, and helps maintain cellular integrity

10.1096/fasebj.31.1_supplement.602.15 FASEB J 163 StringerJ.GroenewegenE.LiewS